Melva Silitonga1 
,
Pasar Maulim Silitonga2,
Erlintan Sinaga1
For correspondence:- Melva Silitonga Email: melvasilitonga@unimed.ac.id
Accepted: 29 April 2023 Published: 30 May 2023
Citation: Silitonga M, Silitonga PM, Sinaga E. Effect of aqueous infusion of Plectranthus amboinicus (LOUR) Spreng leaves on humoral immune system in rats. Trop J Pharm Res 2023; 22(5):1017-1022 doi: 10.4314/tjpr.v22i5.12
© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To examine the effect of an aqueous infusion of Plectranthus amboinicus (AIP) on the immunological development of rats in response to Bacille Calmette-Guerin (BCG) antigen induction.
Methods: Twenty-four male rats, aged 3 months, were separated into six groups. Group 1 was normal control group without treatment, whereas groups 2 and 3 were the treatment groups induced with 100 μL BCG on days 7 and 14, followed by oral administration of AIP at doses of 19 and 31.5 g/kg, respectively. Groups 4 and 5 were treated only with AIP at doses of 19 and 31.5 g/kg respectively. Group 6 was a negative control group induced with 100 μL BCG on days 7 and 14. On day 31, IgG activity, antibody titer, lysozyme activity, relative organ weight, and lung histology were determined.
Results: The results showed that IgG levels, antibody titers, and lysozyme activity were significantly elevated in groups 4, 5, and 6 compared to normal control group (p < 0.05). Aqueous infusion of Plectranthus amboinicus and BCG had no effect on the relative weight of spleen. However, the therapy administered to rats in group 3 significantly increased their liver and lung mass (p < 0.05).
Conclusion: Aqueous infusion of Plectranthus amboinicus leaves stimulates the immune system in BCG-induced rats
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